张延东

课题组长，教授，博士生导师
电话：（0592）2181902
传真：（0592）2181902
电子邮箱： ydzhang@xmu.edu.cn  
课题组主页： http://zhanglab.xmu.edu.cn/

个人简历：

教授（维多利亚vic309官网，2017年8月至今）
副教授（维多利亚vic309官网, 2011年1月-2017年7月）
博士后研究员 （美国哥伦比亚大学，2008-2010， Danishefsky教授）
博士（北京大学，2004-2008，杨震教授)
硕士（北京大学，1999-2002，陈家华教授）
学士（北京理工大学和中科院化学所，1994-1998，江英彦教授）

荣誉与获奖：

田昭武学科交叉奖（2021）,祥华特聘教授（2020）,建行奖教金（2018）,福建省高校新世纪优秀人才支持计划（2016）,金达威特聘教授（2015）,清源奖教金（2014）,金达威一等奖教金（2012）,杜邦奖学金（2006） ,罗氏创新化学奖（2006）,光华奖学金（2001）

主讲课程：
本科生：《有机化学一》，《有机化学二》，《有机化学研讨课一》，《有机化学研讨课二》，《有机化学新兴领域简介》，《化学基础I》、《合成化学I》；

研究生：《化学研究前沿之有机化学》

担任职务：有机化学研究所所长，有机化学课程组组长

研究兴趣：

碳氢官能化促进的活性天然产物全合成、海洋药物化学、天然产物化学生物学

近期主要代表论著：

1. 01. Cui, H.+; Shen, Y.+; Chen, Y.; Wang, R.; Wei, H.; Fu, P.; Lei, X.; Wang, H.; Bi, R.; Zhang, Y.* Two-Stage Syntheses of Clionastatins A and B. J. Am. Chem. Soc. 2022, 144, 8938–8944.

2. 02. Shen, Y.⁺; Li, L.⁺; Xiao, X.⁺; Yang, S.; Hua, Y.; Wang, Y.; Zhang, Y.-w.;* Zhang, Y.* Site-Specific Photochemical Desaturation Enables Divergent Syntheses of Illicium Sesquiterpenes. J. Am. Chem. Soc. 2021, 143, 3256–3263.

3. 03. Jiang, X.⁺; Zeng, Z.⁺; Hua, Y.⁺; Xu, B.; Shen, Y.; Xiong, J.; Qiu, H.; Wu, Y.; Hu, T.;* Zhang, Y.* Merging C–H Vinylation with Switchable 6π-Electrocyclizations for Divergent Heterocycle Synthesis. J. Am. Chem. Soc. 2020, 142, 15585–15594.

4. 04. Chen, R.⁺; Zhang, F.⁺; Hua, Y.⁺; Shi, D.; Lei, X.; Xiao, H.; Wang, Y.; Zhang, Y.* Total Synthesis of Stemarene and Betaerene Diterpenoids: Divergent Ring-Formation Strategy and Late-Stage C−H Functionalization. CCS Chem. 2022, 4, 987–995.

5. 05. Chen, R.; Shen, Y.; Yang, S.; Zhang, Y.* Conformational Design Principles in Total Synthesis. Angew. Chem. Int. Ed. 2020, 59, 14198–14210.

6. 06. Xu, B.⁺; Jiang, X.⁺; Xiong, J.; Lan, J.; Tian, Y.; Zhong, L.; Wang, X.; Xu, N.; Cao, H.; Zhang, W.; Zhang, H.; Hong, X.; Zhan, Y.-y.;* Zhang, Y.;* Hu, T.* Structure-Activity Relationship Study Enables the Discovery of a Novel Berberine Analogue as RXRα Activator to Inhibit Colon Cancer. J. Med. Chem. 2020, 63, 5841–5855.

7. 07. Liu, C.⁺; Chen, R.⁺; Shen, Y.; Liang, Z.; Hua, Y.; Zhang, Y.* Total Synthesis of Aplydactone by a Conformationally Controlled C−H Functionalization. Angew. Chem. Int. Ed. 2017, 56, 8187–8190.

8. 08. Li, J.; Zhao, H.; Jiang, X.; Wang, X.; Hu, H.; Yu, L.; Zhang, Y.* The Cyano Group as a Traceless Activation Group for the Intermolecular [3+2] Cycloaddition of Azomethine Ylides: A Five-Step Synthesis of (±)-Isoretronecanol. Angew. Chem. Int. Ed. 2015, 54, 6306–6310.

9. 09. Zhang, F.; Niu, Y.; Hong, D.; Ye, Y.; Hua, Y.; Ding, S.; Zhang, Y.* Synthetic Studies towards Atkamine. Chin. Chem. Lett. 2021, 32, 668–671.

10. 10. Zeng, Z.; Zhao Y.; Zhang, Y.* Divergent total syntheses of five illudalane sesquiterpenes and assignment of the absolute configuration. Chem. Commun. 2019, 55, 4250–4253.

11. 11. Chen, R.; Li, L.; Lin, N.; Zhou, R.; Hua, Y.; Deng, H.; Zhang, Y.* Asymmetric Total Synthesis of (+)-Majusculoic Acid via a Dimerization–Dedimerization Strategy and Absolute Configuration Assignment. Org. Lett. 2018, 20, 1477–1480.

12. 12. Lin, M.; Cai, P.-J.; Zeng, Z.; Lin, N.; Shen, Y.; Tang, B.; Li, F.; Chen, C.; Yu, Z.-X.;* Zhang, Y.* Conformational Bias by a Removable Silyl Group: Construction of Bicyclo[n.3.1]alkenes by Ring Closing Metathesis. Chem. Eur. J. 2018, 24, 2334–2338.

13. 13. Jiang, X.+; Zeng, Z.+; Shi, D.; Liu, C.; Zhang, Y.* Divergent total syntheses of pseudoberberine and nitidine through C–H vinylation and switchable 6π electrocyclizations. Tetrahedron Lett. 2021, 66, 152839.

14. 14. Chen, R.; Yang, S.; Zhang, Y.* Recent progress in the total synthesis of marine brominated sesquiterpene aplydactone. Org. Biomol. Chem. 2020, 18, 1036–1045.

15. 15. Lin, M.; Cui, H.; Hua, Y.; Zhang, Y.* Domino enyne metathesis en route to skeletally diverse, privileged scaffolds: synthesis of the tricyclic core of pseudolaric acid F. Org. Chem. Front. 2019, 6, 2771–2774.

16. 16. Zeng, Z.; Chen, C.; Zhang, Y.* Enantioselective total synthesis of periconiasin A. Org. Chem. Front. 2018, 5, 838–840.

17. 17. Li, J.; Ye, Y.; Zhang, Y.* Cycloaddition/annulation strategies for the construction of multisubstituted pyrrolidines and their applications in natural product synthesis. Org. Chem. Front. 2018, 5, 864–892.

18. 18. Liu, C.; Zeng, Z.; Chen, R.; Jiang, X.; Wang, Y.; Zhang, Y.* Total Synthesis of (+)-Fusarisetin A Driven by a One-Pot Four-Reaction Process. Org. Lett. 2016, 18, 624-627.

19. 19. Li, L.; Shen, Y.; Zhang, Y.* Synthetic Progress of Jiadifenolide. Chin. J. Org. Chem. 2016, 36, 439–446.

20. 20. Shen, Y.; Li, L.; Pan, Z.; Wang, Y.; Li, J.; Wang, K.; Wang, X.; Zhang, Y.; Hu, T.; Zhang, Y.* Protecting-Group-Free Total Synthesis of (±)-Jiadifenolide: Development of a [4 + 1] Annulation toward Multisubstituted Tetrahydrofurans. Org. Lett. 2015, 17, 5480–5483.

研究思路：