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卓春祥

发布日期:2019-09-10     浏览次数:次   

教授、博士生导师、课题组长

邮箱：cxzhuo@xmu.edu.cn

地址：卢嘉锡楼616，

　　　福建省厦门市思明区思明南路422号，361005 

课题组网站：http://zhuolab.xmu.edu.cn/

ORCID: https://orcid.org/0000-0002-2805-9632

个人简历：

  • 2019.04-至今　　　　维多利亚vic309官网，教授、博士生导师、课题组组长

  • 2014.12-2019.03　　德国马普煤炭所，洪堡学者，博士后（导师：Prof. Alois Fürstner）

  • 2014.07-2014.10　　中国科学院上海有机化学研究所，研究助理（导师：游书力 院士）

  • 2009.09-2014.07　　中国科学院上海有机化学研究所，博士（导师：游书力 院士）

  • 2005.09-2009.07　　湖南大学化学系，学士

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荣誉与获奖情况：

  • 2023 中美化学与化学生物学教授协会“杰出教授奖”(CAPA Distinguished Faculty Award)

  • 2022 Science of Synthesis Early Career Advisory Board

  • 2022 Thieme Chemistry Journals Award

  • 2019 国家高层次青年人才

  • 2019 福建省闽江学者奖励计划特聘教授

  • 2017 国家自然科学二等奖（第五完成人）

  • 2016 上海市自然科学一等奖（第五完成人）

  • 2015 中国科学院优秀博士论文

  • 2015 德国洪堡奖学金

  • 2014 中国科学院院长奖学金特别奖

  • 2014 中国科学院优秀毕业生

  • 2013 “Lecture Award” of the Roche and RSC International Chemistry Symposium

  • 2013 “Student Travel Award” of the Roche and RSC International Chemistry Symposium

  • 2013博士生国家奖学金

  • 2013 M. Braun奖学金

  • 2013 汪猷奖学金

  • 2008 湖南大学大学生创新实验一等奖

  • 2008 本科生国家奖学金


研究兴趣：
新型有机合成方法学;不对称催化;活性天然产物及药物分子的合成

近期主要代表论著：

  1. 35. Yu, Y.-Z.; Su, H.-Y.; Zhuo, C.-X.* Anilines formation via molybdenum-catalyzed intermolecular reaction of ynones with allylic amines. Angew. Chem. Int. Ed. 2024, e202412299.

  2. 34. Wang, J.-L.#; Li, J.-T.#; Wu, G.-Y.; Zhuo, C.-X.* Recent advances in molybdenum catalyzed asymmetric organic transformations. Trends Chem. 2024, 6, 487−501. (# Equal contribution)

    (Invited contribution to the Special issue: Emerging leaders in chemistry)

    Highlighted by Meet our emerging leaders in chemistry – part II. Trends Chem. 2024, 6, 409−414.

  3. 33. Wang, J.-L.#; Wu, G.-Y. #; Luo, J.-N.; Liu, J.-L.; Zhuo, C.-X.*Catalytic intermolecular deoxygenative coupling of carbonyl compounds with alkynes by a Cp*Mo(II)-catalyst. J. Am. Chem. Soc. 2024, 146, 5605−5613. (# Equal contribution)

  4. 32. Li, J.-T.; Fang, G.; Wu, G.-Y.;Zhuo, C.-X.* Modular access to diverse amphoteric α-boryl aldehydes or borylated heterocycles via photoredox catalysis. ACS Catal. 2023, 13, 12648−12655.

  5. 31. Dong, Y.-Q.#; Shi, X.-N.#; Cao, L.-Y.#; Bai, J.; Zhuo, C.-X.* Molybdenum-catalyzed carbonyl-carbonyl olefination reaction for heterocycle syntheses. Org. Chem. Front. 2023, 10, 3544−3552. (# Equal contribution)

  6. 30. Yu, Y.-Z.; Bai, J.; Peng, J.-M.; Yao, J.-S.; Zhuo, C.-X.* Modular access to meta-substituted benzenes via Mo-catalyzed intermolecular deoxygenative benzene formation. J. Am. Chem. Soc. 2023, 145, 8781−8787. (Selected as JACS Supplementary Cover) (Top 20 most downloaded articles in April 2023)

    Highlighted by Org. Process Res. Dev. 2023, 27, 993.

  7. 29. Shi, X.-N.; Wang, J.-L.; Wu, J.-B.; Zhuo, C.-X.* Synthesis of 2-boryl allylboronates by a bimetallic platinum/zinc-promoted diborylation of propargylic amines. Synlett 2023, 34, 1573−1574. (Invited contribution to the Special Edition Thieme Chemistry Journals Awardees 2022)

  8. 28. Cao, L.-Y.; Wang, J.-L.; Wang, K.; Wu, J.-B.; Wang, D.-K.; Peng, J.-M.; Bai, J.; Zhuo, C.-X.* Catalytic asymmetric deoxygenative cyclopropanation reactions by a chiral salen-Mo catalyst. J. Am. Chem. Soc. 2023, 145, 2765–2772. (Selected as JACS Supplementary Cover)

  9. 27. Dong, Y.-Q.#; Wang, K.#; Zhuo, C.-X.* Molybdenum-catalyzed intermolecular deoxygenative cross coupling reactions of 1,2-diketones with ɑ-ketoamides. ACS Catal. 2022, 12, 11428–11435. (# Equal contribution) Top 20 most downloaded articles in October 2022.

  10. 26. Li, J.-T.; Luo, J.-N.; Wang, J.-L.; Wang, D.-K.; Yu, Y.-Z.; Zhuo, C.-X.* Stereoselective intermolecular radical cascade reactions of tryptophans or ɤ-alkenyl-α-amino acids with acrylamides via photoredox catalysis. Nat. commun. 2022, 13, 1778. DOI: 10.1038/s41467-022-29464-5.

  11. 25.Wang, J.-L.; Zhuo, C.-X.*Catalytic deoxygenative cyclopropanation of 1,2-dicarbonyl or monocarbonyl compounds via molybdenum catalysis. Synlett 2022, 33, 599–608. (Invited Synpacts)

  12. 24. Cao, L.-Y.; Luo, J.-N.; Yao, J.-S.; Wang, D.-K.; Dong, Y.-Q.; Zheng, C.; Zhuo, C.-X.* Molybdenum-catalyzed deoxygenative cyclopropanation of 1,2-dicarbonyl or mono-carbonyl compounds. Angew. Chem. Int. Ed. 2021, 60, 15254–15259.

    Highlighted by Nature Catalysis 2021, 4, 347.

    Highlighted by WileyChem, X-MOL, 研之成理, CBG.

  13. 23. Zhuo, C.-X.; Fürstner, A.* Catalysis-based total syntheses of pateamine A and DMDA-Pat A. J. Am. Chem. Soc. 2018, 140, 10514–10523.

    Highlighted by Synfacts 2018, 14, 1114.

    Top 20 most downloaded articles in September, 2018.

  14. 22. Zhuo, C.-X.; Fürstner, A.* Concise synthesis of a pateamine A analogue with in vivo anticancer activity based on an iron catalyzed pyrone ring-opening/cross coupling. Angew. Chem. Int. Ed. 2016, 55, 6051-6056.

  15. 21. Zhuo, C.-X.; Zhang, X.; You, S.-L.* Enantioselective synthesis of pyrrole fused piperazine and piperazinone derivatives via Ir-catalyzed asymmetric allylic amination. ACS Catal. 2016, 6, 5307−5310.

    Highlighted by Synfacts 2016, 12, 1043.

  16. 20. Zhuo, C.-X.; Zhou, Y.; Cheng, Q.; Huang, L.; You, S.-L.* Enantioselective construction of spiroindolines with three contiguous stereogenic centers and chiral tryptamine derivative via the reactive spiroindolenine intermediates. Angew. Chem. Int. Ed. 2015, 54, 14146-14149.

    Highlighted by Synfacts 2016, 12, 151.

  17. 19. Zhuo, C.-X.; Cheng, Q.; Liu, W.-B.; Zhao, Q.; You, S.-L.* Enantioselective synthesis of pyrrole based spiro- and polycyclic derivatives via Ir-catalyzed asymmetric allylic dearomatization and controllable migration reactions. Angew. Chem. Int. Ed. 2015, 54, 8475-8479.

    Highlighted by Synfacts 2015, 11, 944.

  18. 18. Zhuo, C.-X.; Zhou, Y.; You, S.-L.* Highly regio- and enantioselective synthesis of poly-substituted 2H-pyrroles via Pd-catalyzed intermolecular asymmetric allylic dearomatization of pyrroles. J. Am. Chem. Soc. 2014, 136, 6590-6593.

    Highlighted by J. Am. Chem. Soc. Spotlights (J. Am. Chem. Soc. 2014, 136, 6511.)

    Highlighted by the highlight module located on the homepage of JACS (May 5, 2014 – May 15, 2014.)

    Highlighted by Synfacts 2014, 10, 820. & Organic Chemistry Portal.

  19. 17. Zhuo, C.-X.; Zheng, C.; You, S.-L.* Transition-metal catalyzed asymmetric allylic dearomatization reactions. Acc. Chem. Res. 2014, 47, 2558-2573.

  20. 16. Zhuo, C.-X.; You, S.-L.* Palladium-catalyzed intermolecular allylic dearomatization reaction of a-substituted-β-naphthol derivatives: scope and mechanistic investigation. Adv. Synth. Catal. 2014, 356, 2020-2028.

  21. 15. Zhuo, C.-X.; You, S.-L.* Palladium-catalyzed intermolecular asymmetric allylic dearomatization reaction of naphthol derivatives. Angew. Chem. Int. Ed. 2013, 52, 10056-10059.

    Highlighted by Synfacts 2013, 9, 1308. &Chin. J. Org. Chem. 2013, 33, 2440.

  22. 14. Zhuo, C.-X.; Wu, Q.-F; Zhao, Q.; Xu, Q.-L.; You, S.-L.* Enantioselective functionalization of indoles and pyrroles via an in-situ formed spiro-intermediate. J. Am. Chem. Soc. 2013, 135, 8169-8172.

    Highlighted by Synfacts 2013, 9, 874.

  23. 13. Zhuo, C.-X.; Zhang, W.*; You, S.-L.* Catalytic asymmetric dearomatization reactions. Angew. Chem. Int. Ed. 2012, 51, 12662-12686.

  24. 12. Zhuo, C.-X.; Liu, W.-B.; Wu, Q.-F.; You, S.-L.* Asymmetric dearomatization of pyrroles via Ir-catalyzed allylic substitution reaction: enantioselective synthesis of spiro-2H-pyrroles. Chem. Sci. 2012, 3, 205-208.

  25. 11. Zheng, C.*; Zhuo, C.-X.; You, S.-L.* Mechanistic insights into the Pd-catalyzed intermolecular asymmetric allylic dearomatization of multisubstituted pyrroles: understanding the remarkable regio- and enantioselectivity. J. Am. Chem. Soc. 2014, 136, 16251-16259.

  26. 10. Ye, K.-Y.; Cheng, Q.; Zhuo, C.-X.; You, S.-L.* An iridium(I) N-heterocyclic carbene complex catalyzes asymmetric intramolecular allylic amination reactions. Angew. Chem. Int. Ed. 2016, 55, 8113-8116.

  27. 9. Wu, Q.-F; Zheng, C.*; Zhuo, C.-X.; You, S.-L.* Highly efficient synthesis and stereoselective migration reactions of chiral five-membered aza-spiroindolenines: scope and mechanistic understanding. Chem. Sci. 2016, 7, 4453-4459.

  28. 8. Zhou, Y.; Zhuo, C.-X.; Gu, Q.; You, S.-L.* Intermolecular dearomatization reaction of pyrroles promoted by silica gel. Adv. Synth. Catal. 2015, 357, 912-916 (VIP).

  29. 7. Wang, S.-G.; Yin, Q.; Zhuo, C.-X.; You, S.-L.* Asymmetric dearomatization of β-naphthols through an amination reaction catalyzed by a chiral phosphoric acid. Angew. Chem. Int. Ed. 2015, 54, 647-650.

  30. 6. Yang, Z.-P.; Zhuo, C.-X.; You, S.-L.* Ruthenium-catalyzed intramolecular allylic dearomatization/migration reaction of indoles and pyrroles. Adv. Synth. Catal. 2014, 356, 1731-1734.

  31. 5. Zhao, Q.; Zhuo, C.-X.; You, S.-L.* Enantioselective synthesis of N-allylindoles via palladium-catalyzed allylic amination/oxidation of indolines. RSC Adv. 2014, 4, 10875-10878.

  32. 4. Xu, Q.-L.; Zhuo, C.-X.; You, S.-L.* Highly enantioselective synthesis of tetrahydrocarbolines via iridium-catalyzed intramolecular Friedel-Crafts type allylic alkylation reactions. Org. Lett. 2013, 15, 5909-5911.

  33. 3. Liu, W.-B.; Zheng, C.; Zhuo, C.-X.; Dai, L.-X.; You, S.-L.* Ir-catalyzed allylic alkylation reaction with N-aryl phosphoramidite ligands: scope and mechanistic studies. J. Am. Chem. Soc. 2012, 134, 4812-4821.

  34. 2. Wu, Q.-F.; Liu, W.-B.; Zhuo, C.-X.; Rong, Z.-Q.; Ye, K.-Y.; You, S.-L.* Iridium-catalyzed intramolecular asymmetric allylic dearomatization of phenols. Angew. Chem. Int. Ed. 2011, 50, 4455-4458.

  35. 1. Xia, J.-B.; Zhuo, C.-X.; You, S.-L.* Synthesis of Cyclopropane-containing Building Blocks via Ir-Catalyzed Enantioselective Allylic Substitution Reaction. Chin. J. Chem. 2010, 28, 1525-1528.


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